If you have a very large infestation you may see bed bugs crawling in your home; however the most common first sign of bed bugs is bites on the people living in your house. These bites are most often found on arms, legs, or other body parts that are exposed while a person is sleeping. Bed bug bites usually manifest themselves as itchy welts that appear in a zigzag pattern. The actual bite of a bed bug is painless due to a numbing agent that is discharged when the bug bites, however, most people develop an allergic reaction to the saliva which causes the welts. Unfortunately bed bug bites are often hard to distinguish from other common bites like that of mosquitos, fleas, or spiders. It is also important to note that you may have two people living in the home and while one may have a reaction to bed bug bites the other person may not.